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Tapentadol is typically started at a low dose and gradually increased until pain is under control. Dosage should be individualized based on pain severity, therapy response, prior treatment experience and risk factors of addiction, abuse and misuse. Immediate-release tapentadol tablets are typically prescribed with an initial dosage of 50 to 100 mg taken orally every four to six hours as needed for pain relief. Additional doses may be prescribed for the first day of use to achieve optimum pain relief. The maximum dosage for immediate-release tapentadol tablets is 700 mg on the first day and 600 mg on subsequent days. Extended-release tapentadol tablets are typically prescribed with an initial dosage of 50 mg taken twice per day. The maximum dosage of extended-release tapentadol tablets is 500 mg per day.
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Tapentadol is a powerful analgesic that provides relief from moderate to severe pain. Tapentadol works by inhibiting the reuptake of norepinephrine, serotonin and dopamine in the brain. This allows tapentadol to have a strong anti-depressant effect as well. tapentadol can also be used as adjuvant therapy for patients with chronic musculoskeletal pain who are not responding adequately to treatment with non-opioid analgesics or antidepressants alone. tapentadol has been approved for use in Europe since 1997 and was approved in America only recently, under the trade name Nucynta (tapentadol).
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